NEWS

01.06.2018 Systematic characterization of 21 post-translational protein modifications

To more broadly understand the LC-MS/MS characteristics of PTMs, we synthesized and analyzed ~5,000 peptides representing 21 different naturally occurring modifications of lysine, arginine, proline and tyrosine side chains and...[more]



03.04.2018 Mining the human tissue proteome for protein citrullination

Citrullination is a post-translational modification of arginine catalyzed by five peptidylarginine deiminases (PADs) in humans. The loss of a positive charge may cause structural or functional alterations and while the...[more]



05.02.2018 Peptide level turnover measurements enable the study of proteoform dynamics

The coordination of protein synthesis and degradation regulating protein abundance is a fundamental process in cellular homeostasis. Today, mass spectrometry-based technologies allow determination of endogenous protein turnover...[more]



21.12.2017 Richtzenhain-Preis for outstanding dissertation

We congratulate our former lab member Susan Kläger for being awarded with the "Richtzenhain-Preis" of the DKFZ (German Cancer Research Center) for her outstanding dissertation.[more]



01.12.2017 "The target landscape of clinical kinase drugs" published in Science

Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the “druggable” kinome, highlighted...[more]



03.11.2017 Pharmacoproteomic characterisation of human colon and rectal cancer

Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome‐guided pre‐clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the...[more]



02.11.2017 ProteomicsDB highlighted in Nucleic Acids Research

ProteomicsDB is a protein-centric in-memory database for the exploration of large collections of quantitative mass spectrometry-based proteomics data and is highlighted in the database issue of Nucleic Acids Research.[more]



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