05.02.2018 Peptide level turnover measurements enable the study of proteoform dynamics

The coordination of protein synthesis and degradation regulating protein abundance is a fundamental process in cellular homeostasis. Today, mass spectrometry-based technologies allow determination of endogenous protein turnover...[more]

21.12.2017 Richtzenhain-Preis for outstanding dissertation

We congratulate our former lab member Susan Kläger for being awarded with the "Richtzenhain-Preis" of the DKFZ (German Cancer Research Center) for her outstanding dissertation.[more]

01.12.2017 "The target landscape of clinical kinase drugs" published in Science

Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the “druggable” kinome, highlighted...[more]

03.11.2017 Pharmacoproteomic characterisation of human colon and rectal cancer

Most molecular cancer therapies act on protein targets but data on the proteome status of patients and cellular models for proteome‐guided pre‐clinical drug sensitivity studies are only beginning to emerge. Here, we profiled the...[more]

02.11.2017 ProteomicsDB highlighted in Nucleic Acids Research

ProteomicsDB is a protein-centric in-memory database for the exploration of large collections of quantitative mass spectrometry-based proteomics data and is highlighted in the database issue of Nucleic Acids Research.[more]

16.10.2017 Target and identify: triazene linker helps identify azidation sites of labelled proteins

A Triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy. A method for identifying probe modification of proteins via tandem mass spectrometry was developed.[more]

05.09.2017 PROCAL: A set of 40 synthetic peptide standards for proteomics

Here, we describe PROCAL (ProteomeTools Calibration Standard), a set of 40 synthetic peptides standards for retention time indexing, column performance monitoring and collision energy calibration.[more]

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